Journal article
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
Abstract
BACKGROUND: High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal.
METHODS: We …
Authors
Voight BF; Peloso GM; Orho-Melander M; Frikke-Schmidt R; Barbalic M; Jensen MK; Hindy G; Hólm H; Ding EL; Johnson T
Journal
The Lancet, Vol. 380, No. 9841, pp. 572–580
Publisher
Elsevier
Publication Date
8 2012
DOI
10.1016/s0140-6736(12)60312-2
ISSN
0140-6736