Journal article
Diverse Effects of Gut-Derived Serotonin in Intestinal Inflammation
Abstract
The gut is the largest producer of serotonin or 5-hydroxytryptamine (5-HT) in the human body, and 5-HT has been recognized as an important signaling molecule in the gut for decades. There are two distinct sources of enteric 5-HT. Mucosal 5-HT is predominantly produced by enterochromaffin (EC) cells of the gastrointestinal (GI) tract, and neuronal 5-HT in the gut is produced by serotonergic neurons of the enteric nervous system (ENS). The …
Authors
Shajib S; Baranov A; Khan WI
Journal
ACS Chemical Neuroscience, Vol. 8, No. 5, pp. 920–931
Publisher
American Chemical Society (ACS)
Publication Date
May 17, 2017
DOI
10.1021/acschemneuro.6b00414
ISSN
1948-7193