Journal article
Platelet autoantibodies in the bone marrow of patients with immune thrombocytopenia
Abstract
Autoantibodies cause platelet destruction in patients with immune thrombocytopenia (ITP); yet only 50% to 60% of patients have detectable platelet autoantibodies in peripheral blood. We hypothesized that in some ITP patients, platelet autoantibodies are sequestered in the bone marrow where pathological immune reactions target megakaryocytes or newly formed platelets. In this study, we modified the platelet glycoprotein-specific assay to test …
Authors
Shrestha S; Nazy I; Smith JW; Kelton JG; Arnold DM
Journal
Blood Advances, Vol. 4, No. 13, pp. 2962–2966
Publisher
American Society of Hematology
Publication Date
July 14, 2020
DOI
10.1182/bloodadvances.2020001846
ISSN
2473-9529