Acid secretion by isolated primate gastric mucosa. Journal Articles

abstract

• Pentagastrin, histamine, and acetylcholine stimulated acid secretion in the isolated rhesus (Macaca mulatta) gastric mucosa. The potencies were in the order pentagastrin greater than histamine greater than acetylcholine. However, histamine was more effective, the calculated maximal response being twice as great as for the other two agonists. Metiamide inhibited acid secretion induced by both histamine and pentagastrin. Whereas the inhibition of histamine by metiamide was surmountable, that of pentagastrin was not. Atropine inhibited the response to acetylcholine. Even in higher doses, atropine had no effect on histamine. With stimulation, transmucosal potential differences and resistances decreased; the changes were reversed on inhibition.

authors

• Rangachari, Patangi

status

• published 

publication date

• June 1, 1979

has subject area

• Acetylcholine (MeSH)
• Animals (MeSH)
• Cardiovascular System & Hematology (Science Metrix)
• Dose-Response Relationship, Drug (MeSH)
• Female (MeSH)
• Gastric Juice (MeSH)
• Gastric Mucosa (MeSH)
• Haplorhini (MeSH)
• Histamine (MeSH)
• Macaca mulatta (MeSH)
• Male (MeSH)
• Pentagastrin (MeSH)
• Stomach (MeSH)

published in

• American Journal of Physiology  Journal

keywords

• Acetylcholine
• Animals
• Dose-Response Relationship, Drug
• Female
• Gastric Juice
• Gastric Mucosa
• Haplorhini
• Histamine
• Macaca mulatta
• Male
• Pentagastrin
• Stomach

Digital Object Identifier (DOI)

• 10.1152/ajpendo.1979.236.6.e733

PubMed ID

• 109016

start page

• E733

end page

• E733

volume

• 236

issue

• 6