Journal article
Highly Multiplexed Confocal Fluorescence Lifetime Microscope Designed for Screening Applications
Abstract
Protein-protein interactions can be measured in live cells, at nanometer scale, using Fluorescence Lifetime Imaging Microscopy (FLIM) enabled Forster Resonance Energy Transfer (FRET). There are growing interests in exploring protein-protein interactions in drug discovery applications. Traditional single point confocal microscopes, however, are slow and unsuited to small molecule screening, especially when combined with FLIM-FRET. We developed a …
Authors
Hirmiz N; Tsikouras A; Osterlund EJ; Richards M; Andrews DW; Fang Q
Journal
IEEE Journal of Selected Topics in Quantum Electronics, Vol. 27, No. 5, pp. 1–9
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
DOI
10.1109/jstqe.2020.2997834
ISSN
0792-1233