A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2 Academic Article uri icon

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abstract

  • In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date, it has resulted in ~9 million confirmed cases and caused almost 500 000 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socioeconomic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a "cytokine storm" leading to acute respiratory distress syndrome, endothelitis, thromboembolic complications, and multiorgan failure. The epidemiologic features of COVID-19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID-19-related topics should be based on more coordinated high-quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19, and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development, and epidemiology. A total of 150 questions were answered by experts in the field providing a comprehensive and practical overview of COVID-19 and allergic disease.

authors

  • Jimenez Saiz, Rodrigo
  • Riggioni, Carmen
  • Comberiati, Pasquale
  • Giovannini, Mattia
  • Agache, Ioana
  • Akdis, Mübeccel
  • Alves‐Correia, Magna
  • Antó, Josep M
  • Arcolaci, Alessandra
  • Azkur, Ahmet Kursat
  • Azkur, Dilek
  • Beken, Burcin
  • Boccabella, Cristina
  • Bousquet, Jean
  • Breiteneder, Heimo
  • Carvalho, Daniela
  • De las Vecillas, Leticia
  • Diamant, Zuzana
  • Eguiluz‐Gracia, Ibon
  • Eiwegger, Thomas
  • Eyerich, Stefanie
  • Fokkens, Wytske
  • Gao, Ya‐dong
  • Hannachi, Farah
  • Johnston, Sebastian L
  • Jutel, Marek
  • Karavelia, Aspasia
  • Klimek, Ludger
  • Moya, Beatriz
  • Nadeau, Kari C
  • O'Hehir, Robyn
  • O'Mahony, Liam
  • Pfaar, Oliver
  • Sanak, Marek
  • Schwarze, Jürgen
  • Sokolowska, Milena
  • Torres, María J
  • Veen, Willem
  • Zelm, Menno C
  • Wang, De Yun
  • Zhang, Luo
  • Jiménez‐Saiz, Rodrigo
  • Akdis, Cezmi A

publication date

  • June 14, 2020