Sources of Variability and Improvements in the Measure of GABA using MEGA-PRESS at 3T

With the emergence of research investigating the role of gamma-aminobutyric acid (GABA) in neurological and neuropsychiatric diseases, it is important to understand the variability in GABA as measured through magnetic resonance spectroscopy (MRS) and how this variability may affect the interpretation of results. This review addresses methodological sources of variation documented in the current literature on the measurement of GABA. GABA …