High proliferation rates in Wilms limited to aneuploid lesions

Proliferation rates may determine prognosis under chemo- and radiotherapy independently. If so, distribution over lesions with and without aneuploidy should relate to tumor prognosis as defined by other parameters. Our aim was to study the distribution of (high) proliferation rates over WT related to ploidy status. Routine prospective image cytometry for ploidy and proliferation fraction, using 2.5 and 5c criteria based on published methods, …