Journal article
Sortilin: An unusual suspect in cholesterol metabolism
Abstract
The concentration of low-density lipoprotein (LDL) cholesterol (C) in plasma is a key determinant of cardiovascular disease risk and human genetic studies have long endeavoured to elucidate the pathways that regulate LDL metabolism. Massive genome-wide association studies (GWASs) of common genetic variation associated with LDL-C in the population have implicated SORT1 in LDL metabolism. Using experimental paradigms and standards appropriate for …
Authors
Dubé JB; Johansen CT; Hegele RA
Journal
BioEssays, Vol. 33, No. 6, pp. 430–437
Publisher
Wiley
Publication Date
June 2011
DOI
10.1002/bies.201100003
ISSN
0265-9247