Journal article
TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity
Abstract
Monocyte phenotype and output changes with age, but why this occurs and how it impacts anti-bacterial immunity are not clear. We found that, in both humans and mice, circulating monocyte phenotype and function was altered with age due to increasing levels of TNF in the circulation that occur as part of the aging process. Ly6C+ monocytes from old (18-22 mo) mice and CD14+CD16+ intermediate/inflammatory monocytes from older adults also …
Authors
Puchta A; Naidoo A; Verschoor CP; Loukov D; Thevaranjan N; Mandur TS; Nguyen P-S; Jordana M; Loeb M; Xing Z
Journal
PLOS Pathogens, Vol. 12, No. 1,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.ppat.1005368
ISSN
1553-7366