Herpes zoster is more common with increasing age. Acyclovir, valacyclovir, and famciclovir are FDA-approved for treatment of this infection. However, because of their simple dosing regimens, valacyclovir and famciclovir are the preferred drugs. Elderly patients are at increased riskf or severe disease and complications and should be targeted for antiviral therapy. Corticosteroids can be considered in elderly patients with herpes zoster who have no contraindications. Combination therapy is usually required for treatment of postherpetic neuralgia. Influenza is a major public health problem that causes increased morbidity and mortality among older adults. Vaccination with inactivated virus is the mainstay of influenza control, and diligent efforts to optimize vaccine coverage should be maintained and strengthened, particularly among minority populations. Use of rapid antigen detection tests helps in early diagnosis of influenza, and treatment with antiviral agents within 48 hours of onset of symptoms is strongly recommended. Limiting factors for amantadine use in the elderly are its neurologic side effects and the need to check renal function and reduce the dose accordingly. RSV is a major cause of respiratory infections among both community-dwelling older adults and nursing home residents. RSV infections can be diagnosed with viral culture and rapid antigen detection tests using a nasopharyngeal swab. Currently, there is no FDA-approved therapy other than supportive care for RSV infections in elderly patients.