Abstract Background Salmonellameningitis is a rare and serious infection of the central nervous system following acute Salmonella entericasepsis. For this pathogen, no appropriate model has been reported in which to examine infection kinetics and natural dissemination to the brain. Methods
Five mouse lines including C57BL/6, Balb/c, 129S6-
Slc11a1tm1 Mcg, 129S1/SvImJ, B6.129- Inpp5dtm1 Rkhwere used in the murine typhoid model to examine the dissemination of systemic Salmonella entericaserovar Typhimurium following oral infection. Results
We report data on spontaneous meningitis and brain infection following oral infection of mice with
Salmonella entericaserovar Typhimurium. Conclusion
This model may provide a system in which dissemination of bacteria through the central nervous system and the influence of host and bacterial genetics can be queried.