Successful use of intrathecal colistin in the treatment of <i>Pseudomonas aeruginosa</i> ventriculitis

This case report describes a 56-year-old woman with multi-drug-resistant Pseudomonas aeruginosa ventriculitis secondary to external ventricular drain insertion who was successfully treated with intrathecal colistin, intravenous colistin, and intravenous meropenem. A review of the English-language literature found six similar cases. While the patient did not experience side effects, self-limited paresthesias of the arm were noted in one case report. Intrathecal colistin should be considered as a therapy for ventriculitis when antibiotic choices are limited by resistant organisms. Patients should be monitored for neurological side effects during therapy.

Successful use of intrathecal colistin in the treatment of Pseudomonas aeruginosa ventriculitis Journal Articles