With increasing survival after liver transplantation, the recognition and management of long‐term medical problems becomes increasingly important. Obesity, dyslipidemia, diabetes mellitus, hypertension and metabolic syndrome are common after liver transplantation. Compared to the nontransplant population, liver allograft recipients are at increased risk of developing cardiovascular events, a leading cause of late morbidity and mortality after transplantation. Consequently, early recognition and aggressive management of modifiable cardiovascular risk factors are important. Metabolic bone disease and hyperuricemia are also common after liver transplantation, and require early recognition and timely intervention to prevent or reduce associated morbidity. These medical problems, as well as issues regarding skin disorders and family planning, are discussed in this chapter.