Effect of Inhaled Prostaglandin E2 on Methacholine and Leukotriene D4 Airway Responsiveness in Asthmatic Subjects

Previous studies in asthmatics have demonstrated that the endogenous release of inhibitory prostaglandins limits the bronchoconstrictor response to repeated challenges with exercise and histamine, and that inhaled prostaglandin (PG) E 2 attenuates allergen‐induced asthmatic responses and exercise bronchoconstriction in asthmatics. Inhaled PGE 2 does not significantly attenuate methacholine airway responsiveness. These results, taken together, …