Interspecies Recombination Contributes Minimally to Fluoroquinolone Resistance in Streptococcus pneumoniae Journal Articles uri icon

  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All


  • ABSTRACT Analysis of 71 ciprofloxacin-resistant (MIC ≥ 4 μg/ml) Streptococcus pneumoniae clinical isolates revealed only 1 for which the quinolone resistance-determining regions of the parC , parE , and gyrB genes were genetically related to those of viridans group streptococci. Our findings support the occurrence of interspecies recombination of type II topoisomerase genes; however, its contribution to the emergence of quinolone resistance among pneumococci appears to have been minimal.


  • Bast, Darrin J
  • de Azavedo, Joyce CS
  • Tam, Tiffany Y
  • Kilburn, Laurie
  • Duncan, Carla
  • Mandell, Lionel
  • Davidson, Ross J
  • Low, Donald E

publication date

  • September 2001

has subject area