Journal article
Slit coordinates cardiac morphogenesis in Drosophila
Abstract
Slit is a secreted guidance cue that conveys repellent or attractive signals from target and guidepost cells. In Drosophila, responsive cells express one or more of three Robo receptors. The cardial cells of the developing heart express both Slit and Robo2. This is the first report of coincident expression of a Robo and its ligand. In slit mutants, cardial cell alignment, polarization and uniform migration are disrupted. The heart phenotype of …
Authors
MacMullin A; Jacobs JR
Journal
Developmental Biology, Vol. 293, No. 1, pp. 154–164
Publisher
Elsevier
Publication Date
May 2006
DOI
10.1016/j.ydbio.2006.01.027
ISSN
0012-1606