Journal article
Physiologic Regulation of Melatonin
Abstract
The concentration of melatonin shows a marked diurnal rhythm in the pineal gland and in blood with high levels normally occurring during dark and low levels during light. Synthesis in the pineal gland is controlled by a noradrenergic mechanism regulated by an indirect neural pathway from the eye. The pineal enzymes N-acetyltransferase and hydroxyindole-O-methyltransferase are activated when noradrenaline is released during darkness resulting in …
Authors
Brown G; Niles L; Tsui H; Grota L; Bubenik G
Journal
, , , pp. 95–112
Publisher
Elsevier
Publication Date
1981
DOI
10.1016/b978-0-08-026400-4.50016-5