Urine Screening for Disorders of Mucopolysaccharide Metabolism Academic Article uri icon

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abstract

  • In our laboratory, we have been troubled by difficulties in the interpretation of alcian blue and toluidin blue spot tests for mucopolysacchanide disorders. We have tried to provide the clinician with information that would assist him in diagnosis, but were hampered by the apparent high incidence of "false positive" tests. In response to this problem, we reviewed our expenience with 67 referred patients and with 181 retarded institutionalized patients. A positive correlation between test results and chemical disease was found mainly in patients where the diagnosis of mucopolysaccharidosis was already obvious.

publication date

  • November 1, 1969