This chapter contains sections titled: Introduction Questions Literature‐search strategy and inclusions What is the optimal induction therapy for adolescents with ALL? What is the role of stem cell transplantation for adults with ALL? What is the role of tyrosine kinase inhibitors in adults with philadelphia chromosome positive ALL? References Introduction Questions Literature‐search strategy and inclusions What is the optimal induction therapy for adolescents with ALL? What is the role of stem cell transplantation for adults with ALL? What is the role of tyrosine kinase inhibitors in adults with philadelphia chromosome positive ALL? References