This chapter contains sections titled: Introduction Questions Literature‐search strategy and inclusion How should patients be stratified into risk categories? Which therapy should low‐risk patients receive? Which therapy should high‐risk patients receive? When myelosuppressive therapy is required, how can the risk of leukemogenesis be reduced? References Introduction Questions Literature‐search strategy and inclusion How should patients be stratified into risk categories? Which therapy should low‐risk patients receive? Which therapy should high‐risk patients receive? When myelosuppressive therapy is required, how can the risk of leukemogenesis be reduced? References