This chapter contains sections titled: Introduction Questions Literature‐search strategy and inclusion Do aggressive ALL‐type regimens improve outcome? Does CNS prophylaxis improve outcome, including survival? Does stem cell transplantation after first remission improve outcome? Does the type of transplantation (autologous vs. allogeneic) influence outcome? Does mediastinal radiation improve outcome? References Introduction Questions Literature‐search strategy and inclusion Do aggressive ALL‐type regimens improve outcome? Does CNS prophylaxis improve outcome, including survival? Does stem cell transplantation after first remission improve outcome? Does the type of transplantation (autologous vs. allogeneic) influence outcome? Does mediastinal radiation improve outcome? References