A case report of leptomeningeal involvement of pancreatic carcinoma following whole body hyperthermia

A patient with pancreatic adenocarcinoma was treated with four courses of whole body hyperthermia followed by radiotherapy. Subsequently, the patient relapsed with metastases to the leptomeninges and left optic nerve. Autopsy revealed complete eradication of tumor in the area of primary disease. The unusual course of this patient's clinical course is discussed with regard to her therapy. Previous reports of leptomeningeal and optic nerve metastases from pancreatic carcinoma are reviewed.