Absence of thrombin generation during therapy with a highly purified solvent/detergent treated factor IX concentrate

Traditional factor IX concentrate preparations contain a variety of procoagulants and their use is associated with thromboembolic complications and disseminated intravascular coagulation. A highly purified factor IX concentrate (AlphaNine) has been developed but it has been shown to have the potential for transmitting non A, non B hepatitis. More recently, an alternative highly purified factor IX concentrate (FIX SDHP) with improved viral …