This chapter contains sections titled: Introduction Questions Literature‐search strategy and inclusions What is the recommended treatment for patients with CML at the time of diagnosis? What is the place of bone marrow transplantation at the time of diagnosis? What is the recommended treatment for patients with CML where first line treatment has failed? References Introduction Questions Literature‐search strategy and inclusions What is the recommended treatment for patients with CML at the time of diagnosis? What is the place of bone marrow transplantation at the time of diagnosis? What is the recommended treatment for patients with CML where first line treatment has failed? References