Chapter
Mouse Models of IGF-1R and Cancer
Abstract
A variety of systems have been used to evaluate the role of the insulin-like growth factor (IGF) axis in cancer, including human tissue and serum, cell lines derived from spontaneous tumors from humans and other species, and genetically modified animals. As animal models of the IGF ligands (IGF-I, IGF-II) and IGF-binding proteins have been described elsewhere in this book, this chapter focuses on animal models of altered Igf1r gene expression.
Authors
Campbell CI; Petrik JJ; Moorehead RA
Book title
Insulin-like Growth Factors and Cancer
Pagination
pp. 179-191
Publisher
Springer Nature
Publication Date
2012
DOI
10.1007/978-1-4614-0598-6_9