Filling the Immunological Gap: Recombinant Viral Vectors for Mucosal Vaccines

Most pathogens initiate infection via mucosal routes; consequently effective vaccines that induce relevant innate and adaptive immune responses at mucosal sites are required for protection. Indeed, we are confronted by a number of major global infections, such as HIV and tuberculosis, that have complex methods of pathogenesis, that can be antigenically diverse, and that evolved significant mechanisms to evade human immune responses. The …