This chapter contains sections titled: Introduction Applying an evidence‐based guideline in clinical practice Applying the results of a systematic review in clinical practice Applying the results of a randomized controlled trial in clinical practice Practice of evidence‐based medicine in the absence of high‐quality evidence Choosing the best diagnostic strategy Conclusion References Introduction Applying an evidence‐based guideline in clinical practice Applying the results of a systematic review in clinical practice Applying the results of a randomized controlled trial in clinical practice Practice of evidence‐based medicine in the absence of high‐quality evidence Choosing the best diagnostic strategy Conclusion References