Endogenous thrombin potential and the risk of venous thromboembolism

The Endogenous Thrombin Potential (ETP) is a plasma assay, which measures the effect of activated protein C (APC) on thrombin generation via the activation of the extrinsic coagulation pathway with tissue factor. The result is expressed as a normalized sensitivity ratio (APC-sr). Abnormality of the protein C pathway, such as Factor V Leiden mutation, produces a high ETP result, in contrast to the aPTT-based activated protein C resistance (APCR) …