Effect of hormone replacement therapy on the endogenous thrombin potential

Hormone replacement therapy (HRT) has been associated with a two- to fourfold increased risk of venous thromboembolism (VTE) in recent studies. However, thel explanation for this increase thrombogenicity is still unknown. The endogenous thrombir potential (ETP), which is a measure of the effect of activated protein C (APC) on thrombir generation when the extrinsic coagulation pathway is activated, reflects the activity of thel protein C …