Interleukin 3, Interleukin 5, and Granulocyte–Macrophage Colony‐Stimulating Factor

Several environmental stimuli and inflammatory mediators can induce the release of interleukin 3 (IL‐3), IL‐5, and granulocyte–macrophage colony‐stimulating factor (GM‐CSF) from a number of myeloid and structural cells. These pleiotropic cytokines exhibit some overlapping effects because they share a common receptor β chain (βc) as well as several signal transduction pathways. While not required to maintain steady‐state hematopoiesis, they are …