The Signal Recognition Particle and Its Receptor in ER Protein Targeting

The complex mechanisms that regulate cotranslational targeting of proteins to the endoplasmic reticulum (ER) begin with the translation of a signal sequence in the nascent protein that encodes the required targeting information. In eukaryotes, the recognition and correct sorting of signal sequence-containing polypeptides involves a relatively complicated seven-component ribonucleoprotein complex termed signal recognition particle (SRP) and an …