Incorporation of fragment x into clots increases their susceptibility to lysis

Fragment X (frag X), a clottable degradation product of fibrinogen, accumulates in patients given tissue-type plasminogen activator (tPA). Previously, we demonstrated that frag X incorporation into fibrin (Fn) clots renders them more susceptible to lysis, raising the possibility that tPA-induced frag X formation contributes to bleeding. To explore the mechanism by which frag X incorporation renders clots more susceptible to lysis, we first …