Objective: To evaluate the effectiveness of Medicated γ-IUD compared with other IUDs for contraception. Methods: CBMdisc (1986-2005), VIP (1989-2005), CNKI (1994-2005), The Cochrane Library (Issue 4, 2005) and 10 related journals were searched for randomized controlled trials (RCTs) and quasi-randomized controlled trials (quasi-RCTs) on the comparison between γ-IUD and other IUDs. The quality of included trials was critically appraised. RevMan 4. 2. 8 software was used for statistical analysis. Results: Ten published studies with 8 381 participants were included. The results of meta-analysis were expressed with Peto OR (cumulative pregnancy rate, cumulative expulsion rate, cumulative rate of removing for medical reasons) or OR (cumulative continuation rate) and 95% CI. Compared with MSSR-165, Medicated γ-25,200 resulted in lower pregnancy rate at 1, 2, 3 years of follow-up [with the OR (95% CI) 0.31 (0.15,0.64), 0.31 (0.17,0.54), 0.31 (0.19,0.51), respectively], lower cumulative expulsion rate in 5 year follow-up [0.26 (0.17,0.40), 0.28 (0.20,0.41), 0.30 (0.21,0.42.), 0.29 (0.19,0.44), 0.32 (0.21, 0.48), respectively], lower cumulative rate of removing for medical reasons after 4 year follow-up [0.57 (0.36,0.92)], and higher rate of cumulative continuation in 5 years of follow-up [3.35 (2.29,4.89), 2.76 (2.06,3.69), 2.41 (1.89,3.08), 2.22 (1.69,2.91), 1.99 (1.55,2.55), respectively]. Compared with TCu220, Medicated γ-25,200 resulted in lower cumulative pregnancy rate after follow-up 2, 3 years [0.46 (0.25,0.87); 0.48 (0.27,0.85)], lower cumulative expulsion rate after 1 year follow-up [0.58 (0.35,0.97)], lower cumulative rate of being removed for medical reasons in 5 year follow-up [0.37 (0.23,0.59), 0.38 (0.26,0.56), 0.45 (0.32,0.64), 0.47 (0.30,0.73), 0.58 (0.39,0.87), respectively] and higher rate of cumulative continuation in 5 years of follow-up [2.15 (1.61,2.87), 2.02 (1.56,2.63), 1.72 (1.34,2.20), 1.44 (1.08,1.91), 1.39 (1.07,1.80), respectively]. Compared with Uterus-Cu, Medicated γ-25,200 resulted in higher rate of cumulative continuation after follow-up 1 year [0.51 (0.34, 0.77)]. Compared with MLCu375, Medicated γ-25,200 resulted in lower cumulative rate of being removed for medical reasons and higher rate of cumulative continuation after follow-up for 3 years [0.22 (0.09,0.52), 2.84 (1.64,4.94)]. Compared with TCu380A, Medicated γ-25, 200 resulted in lower cumulative rate of being removed for medical reasons and higher rate of cumulative continuation in follow-up for 2 years [0.36 (0.18,0.73), 0.29 (0.12,0.70); 3.06 (1.72,5.44), 3.61 (1.75,7.47)]. Conclusions: Available evidence shows that Medicated γ-IUD has better or equal effectiveness when compared with other IUDs. However, more RCTs with high quality and longer follow-up period are needed to confirm the conclusion.