Manganese: a unique neuroimaging contrast agent

Manganese is a strong magnetic resonance imaging relaxation agent with unique biological properties that make it suitable for in vivo studies of neuroachitecture, neuronal tracts and neuronal function in animals. However, in humans large doses of manganese are neurotoxic and cause damage, primarily to the basal ganglia, resulting in a form of parkinsonism termed manganism. If low doses can be safely used and detected in the human brain, manganese will provide insight into neuroanatomy, connectivity, function and neuropathology.