Manganese: a unique neuroimaging contrast agent Journal Articles

abstract

• Manganese is a strong magnetic resonance imaging relaxation agent with unique biological properties that make it suitable for in vivo studies of neuroachitecture, neuronal tracts and neuronal function in animals. However, in humans large doses of manganese are neurotoxic and cause damage, primarily to the basal ganglia, resulting in a form of parkinsonism termed manganism. If low doses can be safely used and detected in the human brain, manganese will provide insight into neuroanatomy, connectivity, function and neuropathology.

authors

• Bock, Nicholas
• Silva, Afonso C

status

• published 

publication date

• May 2007

has subject area

• 1103 Clinical Sciences (FoR)
• 1109 Neurosciences (FoR)
• 1702 Cognitive Sciences (FoR)
• Neurology & Neurosurgery (Science Metrix)

published in

• Future Neurology  Journal

keywords

• 1 Underpinning research
• 1.1 Normal biological development and functioning
• 32 Biomedical and Clinical Sciences
• 3202 Clinical Sciences
• 3209 Neurosciences
• Bioengineering
• Biomedical Imaging
• Brain Disorders
• Neurological
• Neurosciences

Digital Object Identifier (DOI)

• 10.2217/14796708.2.3.297

start page

• 297

end page

• 305

volume

• 2

issue

• 3