Objectives and methodology: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET) Academic Article uri icon

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  • A current goal of the Italian Society for Thrombosis and Haemostasis (SISET) is the production of guidelines for clinical conditions related to haemostasis and thrombosis. In 2006, the Executive Committee of SISET adopted a new program for the production of methodologically and scientifically sound guidelines aimed at both addressing clinical practice and stimulating new research. The first major step for this program was to train methodologists to manage working groups that compose the guidelines, and to create a reference document that describes the development of the program. The aim of the present paper is to report a short version of this methodological document, for those who wish to follow SISET guidelines. We start by giving a brief outline of the SISET mission, then present the SISET guideline development process, which includes: project funding, selection of guidelines topics, multidisciplinary group composition, definition of clinical questions, literature search, evidence appraisal, grading recommendations, guideline implementation, external peer review, and guideline updating.


  • Iorio, Alfonso
  • Ageno, Walter
  • Cosmi, Benilde
  • Imberti, Davide
  • Lussana, Federico
  • Siragusa, Sergio
  • Tormene, Daniela
  • Tosetto, Alberto
  • Cattaneo, Marco

publication date

  • November 2009