Journal article
Prothrombin complex concentrates versus fresh frozen plasma for warfarin reversal A systematic review and meta-analysis
Abstract
Urgent reversal of warfarin is required for patients who experience major bleeding or require urgent surgery. Treatment options include the combination of vitamin K and coagulation factor replacement with either prothrombin complex concentrate (PCC) or fresh frozen plasma (FFP). However, the optimal reversal strategy is unclear based on clinically relevant outcomes. We searched in MEDLINE, EMBASE and Cochrane library to December 2015. Thirteen …
Authors
Chai-Adisaksopha C; Hillis C; Siegal DM; Movilla R; Heddle N; Iorio A; Crowther M
Journal
Thrombosis and Haemostasis, Vol. 116, No. 05, pp. 879–890
Publisher
Thieme
Publication Date
September 2016
DOI
10.1160/th16-04-0266
ISSN
0340-6245