Journal article
A systematic review found that deviations from intention-to-treat are common in randomized trials and systematic reviews
Abstract
OBJECTIVES: To describe the characteristics, and estimate the incidence, of trials included in systematic reviews deviating from the intention-to-treat (ITT) principle.
STUDY DESIGN AND SETTING: A 5% random sample of reviews were selected (Medline 2006-2010). Trials from reviews were classified based on the ITT: (1) ITT trials (trials reporting standard ITT analyses); (2) modified ITT (mITT) trials (modified ITT; trials deviating from standard …
Authors
Abraha I; Cozzolino F; Orso M; Marchesi M; Germani A; Lombardo G; Eusebi P; De Florio R; Luchetta ML; Iorio A
Journal
Journal of Clinical Epidemiology, Vol. 84, , pp. 37–46
Publisher
Elsevier
Publication Date
April 2017
DOI
10.1016/j.jclinepi.2016.11.012
ISSN
0895-4356