An electronic database of human hemoglobin variants on the World Wide Web.
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HUMAN HEMOGLOBINS and their variants have been the subjects for fruitful clinical and basic research for many years. The knowledge derived from these studies is essential in understanding the relationship between hemoglobin structures and functions. The report on the seminal study of sickle hemoglobin by Pauling et al1 in 1949 provided the first example of molecular disease. With the advances in molecular biology during the past decades, the study of human globin genes and their mutations continues to lead the way in understanding molecular genetics and its clinical relevance.
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