Prochemerin cleavage by factor XIa links coagulation and inflammation Academic Article uri icon

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abstract

  • Key Points Inactive prochemerin is activated in plasma by coagulation enzymes to active chemerin forms that are adipokines and chemoattractants. FXIa cleaves prochemerin, forming a partially active intermediate that is then fully activated by plasma basic carboxypeptidases.

authors

  • Ge, Xiaomei
  • Yamaguchi, Yasuto
  • Zhao, Lei
  • Bury, Loredana
  • Gresele, Paolo
  • Berube, Caroline
  • Leung, Laurence
  • Morser, John

publication date

  • January 18, 2018

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