Quality management is an important part for enterprise management. There are some main problems concerning with quality decision and analysis, such as production scheme, purchase plan, formula, quality plan and quality inspection specification. For providing reliable and scientific decision support to reduce randomness and blindness, a framework of quality-oriented decision support system (QDSS) was given. Data warehouse (DW), which overcomes disadvantages of traditional database (DB), was adopted. Models and methods used for decision and analysis, i.e. statistical analysis, method of fixing sample size, sensitivity analysis, multivariate linear regression model and fuzzy judgement matrix, were presented. Main process of QDSS was introduced.