Experts has a new look! Let us know what you think of the updates.

Provide feedback
Home
Scholarly Works
A Platform for Generation of Chamber-Specific...
Journal article

A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling

Abstract

Tissue engineering using cardiomyocytes derived from human pluripotent stem cells holds a promise to revolutionize drug discovery, but only if limitations related to cardiac chamber specification and platform versatility can be overcome. We describe here a scalable tissue-cultivation platform that is cell source agnostic and enables drug testing under electrical pacing. The plastic platform enabled on-line noninvasive recording of passive …

Authors

Zhao Y; Rafatian N; Feric NT; Cox BJ; Aschar-Sobbi R; Wang EY; Aggarwal P; Zhang B; Conant G; Ronaldson-Bouchard K

Journal

Cell, Vol. 176, No. 4, pp. 913–927.e18

Publisher

Elsevier

Publication Date

February 2019

DOI

10.1016/j.cell.2018.11.042

ISSN

0092-8674