Fibrotic Response to Biomaterials and all Associated Sequence of Fibrosis

The host response to biomaterials is almost always the formation of a fibrous capsule. After implantation of a biomaterial, the body tries to heal the wound by sequentially causing acute inflammation, granulation tissue and the foreign body response, encapsulation by fibrous tissue, and capsular contracture. These responses are detrimental to many applications of biomaterials. Fibrosis is initiated by surface properties, mechanical signals, and …