Effects of Bisacodyl on Colonic Motor Patterns in Rats

Objective: To explore the effects of bisacodyl on motor patterns in rat colon in vitro. Methods: 19 male rats were divided randomly into two groups: bisacodyl and saline group. Bisacodyl and saline were infused into the proximal or distal colon lumen; spatiotemporal mapping was used to quantify motor patterns. Results: (1) Proximal infusion of bisacodyl induced cluster long distance contractions (LDCs) with 3-8 LDCs in one cluster and frequency …