Journal article
Front Cover: An Unintentional Discovery of a Fluorogenic DNA Probe for Ribonuclease I (ChemBioChem 4/2020)
Abstract
Serendipity: We report the discovery of RFA13‐1, a fluorogenic DNA probe, isolated from a DNA pool (left) against the bacterium Clostridium difficile, which was unintentionally contaminated by another bacterium Klebsiella aerogenes (right). The molecular target of RFA13‐1 has been identified as ribonuclease I from K. aerogenes. We found the selected DNA sequence in RFA13‐1 can assist RNase I (the sharp axe) to efficiently cleave a …
Authors
Chang D; Chang T; Salena B; Li Y
Journal
ChemBioChem, Vol. 21, No. 4, pp. 428–428
Publisher
Wiley
Publication Date
February 17, 2020
DOI
10.1002/cbic.202000038
ISSN
1439-4227