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Front Cover: An Unintentional Discovery of a...
Journal article

Front Cover: An Unintentional Discovery of a Fluorogenic DNA Probe for Ribonuclease I (ChemBioChem 4/2020)

Abstract

Serendipity: We report the discovery of RFA13‐1, a fluorogenic DNA probe, isolated from a DNA pool (left) against the bacterium Clostridium difficile, which was unintentionally contaminated by another bacterium Klebsiella aerogenes (right). The molecular target of RFA13‐1 has been identified as ribonuclease I from K. aerogenes. We found the selected DNA sequence in RFA13‐1 can assist RNase I (the sharp axe) to efficiently cleave a …

Authors

Chang D; Chang T; Salena B; Li Y

Journal

ChemBioChem, Vol. 21, No. 4, pp. 428–428

Publisher

Wiley

Publication Date

February 17, 2020

DOI

10.1002/cbic.202000038

ISSN

1439-4227