keywords ANTISENSE RNA Chemistry Chemistry, Inorganic & Nuclear Chemistry, Medicinal DOWN-REGULATION Drug discovery ESCHERICHIA-COLI GENE-EXPRESSION Gene regulation IDENTIFICATION Life Sciences & Biomedicine MESSENGER-RNAS Metabolite Pharmacology & Pharmacy Physical Sciences Programmable cells RIBOSWITCHES Riboswitch SELECTION SMALL NONCODING RNAS SOLUBLE-RNA Science & Technology sRNA