Synthetic Approaches to the Naturally Occurring Anticancer Amaryllidaceae Alkaloids trans-dihydrolycoricidine and trans-dihydronarciclasine

A comprehensive review on the occurrence, anticancer activity and strategies toward the total synthesis of the biologically active, naturally occurring Amaryllidaceae alkaloids trans-dihydrolycoricidine 3 and trans-dihydronarciclasine 6, as described from a historical perspective.