Total Synthesis of the Natural Product (+)‐trans‐Dihydronarciclasine via an Asymmetric Organocatalytic [3+3]‐Cycloaddition and discovery of its potent anti‐Zika Virus (ZIKV) Activity

Abstract An asymmetric total synthesis of the natural product (+)‐trans‐dihydronarciclasine has been achieved from α‐azidoacetone and cinnamaldehyde precursors via a stepwise asymmetric [3+3]‐organocatalytic cascade. The anti‐Zika virus activity of this compound is also reported for the first time.