Total Synthesis of the Natural Product (+)‐trans‐Dihydronarciclasine via an Asymmetric Organocatalytic [3+3]‐Cycloaddition and discovery of its potent anti‐Zika Virus (ZIKV) Activity Journal Articles uri icon

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abstract

  • AbstractAn asymmetric total synthesis of the natural product (+)‐trans‐dihydronarciclasine has been achieved from α‐azidoacetone and cinnamaldehyde precursors via a stepwise asymmetric [3+3]‐organocatalytic cascade. The anti‐Zika virus activity of this compound is also reported for the first time.

authors

  • Revu, Omkar
  • Zepeda‐Velázquez, Carlos
  • Nielsen, Alex J
  • Mcnulty, James
  • Yolken, Robert H
  • Jones‐Brando, Lorraine

publication date

  • November 2016