Community-Associated Methicillin-ResistantStaphylococcus aureusInfections in Men Who Have Sex With Men: A Case Series Academic Article uri icon

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abstract

  • BACKGROUND: The purpose of the present study was to describe the clinical characteristics and management of community-associated methicillin-resistantStaphylococcus aureus(CA-MRSA) infections among a cohort of men who have sex with men.PATIENTS AND METHODS: A retrospective chart review was conducted of patients with culture-proven MRSA at Maple Leaf Medical Clinic (Toronto, Ontario) between November 2004 and December 2005. Cases were identified by individual physicians and by queries in the clinical management system. A standard data collection form was used to record patient demographics, potential risk factors for MRSA and course of illness. When available, antimicrobial sensitivities were recorded. DNA fingerprinting using pulsed-field gel electrophoresis, and genetic analysis for SCCmectyping and detection of the Panton-Valentine leukocidin cytotoxin were performed on six available isolates.RESULTS: Seventeen patients with MRSA infection were identified, 12 (71%) of whom were HIV-positive. The most common clinical presentation was abscess (35%), followed by furuncle (17%), folliculitis (17%), cellulitis (17%) and sinusitis (12%). The majority of MRSA isolates were resistant to ciprofloxacin (92%) and levofloxacin (77%). All isolates were susceptible to trimethoprim-sulfamethoxazole, rifampin, linezolid, gentamicin and clindamycin, while the majority were susceptible to tetracycline (80%). All six isolates tested were SCCmectype IVa-positive and Panton-Valentine leukocidin-positive, and had fingerprint patterns consistent with the CMRSA-10 (USA300) clone.CONCLUSION: The present study describes the clinical presentation and management of CA-MRSA infections occurring in Toronto among men who have sex with men. The infections appear to have been caused by CMRSA-10, which has caused the majority of CA-MRSA outbreaks elsewhere.

authors

  • Sztramko, Richard
  • Katz, K
  • Antoniou, T
  • Mulvey, MR
  • Brunetta, J
  • Crouzat, F
  • Kovacs, C
  • Merkley, B
  • Tilley, D
  • Loutfy, Mona R

publication date

  • 2007