Journal article
CtIP/Ctp1/Sae2, molecular form fit for function
Abstract
Vertebrate CtIP, and its fission yeast (Ctp1), budding yeast (Sae2) and plant (Com1) orthologs have emerged as key regulatory molecules in cellular responses to DNA double strand breaks (DSBs). By modulating the nucleolytic 5'-3' resection activity of the Mre11/Rad50/Nbs1 (MRN) DSB repair processing and signaling complex, CtIP/Ctp1/Sae2/Com1 is integral to the channeling of DNA double strand breaks through DSB repair by homologous recombination …
Authors
Andres SN; Williams RS
Journal
DNA Repair, Vol. 56, , pp. 109–117
Publisher
Elsevier
Publication Date
August 2017
DOI
10.1016/j.dnarep.2017.06.013
ISSN
1568-7864